Causes of Diabetes – What Are the Risks Involved

The Causes of diabetes are still not fully understood. Neither are medical scientists able to explain why some people develop diabetes and others don’t. Certain factors have, however, been clearly identified which contribute to the development of diabetes.

Is Diabetes Inherited?

Heredity is a major factor. That diabetes can be inherited has been known for centuries. However, the pattern of inheritance is not fully understood. Statistic indicates that those with a family history of the disease have a higher risk of developing diabetes than those without such a background. The risk factor is 25 to 33 percent more.

Children are most likely to develop diabetes if either or both parents are diabetes, or if the expectant mother became diabetic, or if the mother was a confirmed diabetic prior to conception. This may not always be true. It is possible for parents who were, or are diabetic and the other remains free from the disease.

It is, however, essential that the blood sugar level of an expectant mother who is diabetic be maintained within the normal range, so that diabetes is not passed on to her child. It the blood sugar level is kept under control, the infant may not have nay symptoms of inherited diabetes, but a risk factor cannot be ruled out.

One reason why diabetes, especially type-2 diabetes runs in the family is because of the diabetes gene. But even it is caused by genetic factors beyond your control; there is no reason to suffer from it. Diabetes mellitus cannot be cured in full sense of the term, but it can be effectively controlled so that you would not know the difference.

Intensive genetic research is currently underway to identify genes associated with both type-1 and type-2 diabetes. In a study sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases of USA the relatives at risk of type-1 diabetes are being treated with low doses of either insulin or an oral medication to determine if drugs may prevent the disease.

Surveys show that in India diabetes is more prevalent among males than females. In this population, family history of diabetes mellitus was present in 5.5 to 11.6 per cent. Amongst diabetics, 18.3 per cent urban and 6.4 percent of rural population had a direct relative with diabetes. Therefore, genetic predisposition in India is comparable to that observed in other parts of the world.

Diet: A Self inflicted Causes

Diabetes has been described by most medical scientists as a prosperity’ disease, primarily caused by systematic overeating. Not only is eating too much sugar and refined carbohydrates harmful, but proteins and fats, which are transformed into sugar, may also result in diabetes if taken in excess.

Too much food taxes the pancreas and ultimately its normal activity of producing insulin gets paralyzed. It is interesting to note that diabetes is almost unknown in countries where people are poor and cannot afford to overeat.

The incidence of diabetes is directly linked with the consumption of processed foods rich in refined carbohydrates, like biscuits, bread, cakes chocolates, pudding and ice creams. In Britain, during the war when only whole wheat bread was available the incidence of diabetes dropped by 55 percent.

Parents should take great care to develop correct dietary habits in their children. Children should be prevented from becoming addicts to harmful foods like ice cream, cakes, jam, jelly, peppermint, chocolates and other sweets. The amount of food given to children should be such as would allow growth but not obesity. Children should be convinced about the importance of exercise and games and sports should be encouraged. Ideal body weight and a proportionate body is an almost certain guarantee against diabetes.

The Obesity Trigger

Obesity is one of the main causes of diabetes. Studies show that 60 to 85 % of diabetics tend to be overweight. In the United States of America, about 80 percent of type –2 non-insulin dependent diabetics are reported to be overweight. During the Second World War, when there was a decrease in the average weight of the people, the incidence of diabetes came down dramatically. The greater the obesity, the greater is the mortality rate due to complications of diabetes.

Excess fat prevents insulin from working properly. The more fatty tissue in the body, the more resistant the muscle and tissue cells become to body insulin. Insulin allows the sugar in the blood to enter the cells by acting on the receptor sites on the surface of the cells. In obesity, where a person is overweight by 20 percent of the ideal weight or has high uric acid, or some syndromes, receptors are sparse and functionally idle. This is observed in patients developing diabetes around the age of 40 years, and having type-2 non-insulin dependent diabetes. It is estimated that the incidence of diabetes is four times higher in persons of moderate’s obesity and 3 times higher in persons of severe obesity. It has been rightly said; Heredity is like a cannon and obesity pulls and trigger.

Older people often tend to gain weight, and the same time, many of them develop and mild form of diabetes because who are over weight can often improve their blood sugar simply by losing weight. In some cases, it is all that is required to bring blood sugar back into the normal range. Even small weight loss can have beneficial effects, reducing blood sugar levels, or allowing medicines to work better. However, sudden gain in weight may cause diabetes to return. It is therefore important for older people to keep their weight down to normal. Among those detected to be diabetic, almost one third are overweight.

Virus Infections

Pancreatic infections with Coxsackie’s B virus can result in beta cell damage, development of autoantibodies and, consequently, type-1 insulin dependent diabetes mellitus. Some of these can be diagnosed by a viral antibody test and islet cell antibody test. Screening for antibodies can indicate potentially juvenile diabetes in a family on the basis of auto-immunity.

The Lifestyle Risk

A sedentary lifestyle, resulting from lack of physical work and exercise, plays an improvement role in the development of diabetes. The less active a person, the greater the risk of developing diabetes. Modern conveniences have made work easier. Physical activity and exercise helps control weight, uses up a lot of glucose (sugar) present in the blood as energy and makes cells more sensitive to insulin. Consequently, the workload on the pancreas is reduced.

Exercise also adds to the muscles mass. Normally, between 70 percent to 90 percent of the blood sugar is absorbed into the muscles. A reduction in muscle mass-either due to age of physical inactivity—reduces the storage space for blood sugar, and it remains in the blood stream.

Smoking: An Important Risk Factor

Smoking is another important risk factor. Among men who smoke, the risk of developing diabetes is doubled. In women who smoke 25 or more cigarettes a day, the risk of developing diabetes is increased by 40 percent. Smoking also reduces retinal blood flow and increases the risk of developing retinopathy. It also decreases insulin absorption and limits joints mobility. Smoking, in combination with diabetes, greatly enhances the likelihood of premature mortality. It also depends upon the number of cigarettes a day a person smokes and the number of years he has been smoking.

Age

A risk of type-2 diabetes increases, as one grows older, especially above the age of 45 years. Part of the reason is that is people grow older, they tend to become less physically active, lose muscle mass and gain weight. With life styles becoming more sedentary, there has been an increase of diabetes among people in there 30s and 40s.

Stress and Tension

Stress can be emotional or physical, such as a surgery or a serious infection, an accident or an emotional shock. Another very urban trait, the high stress lifestyle, not just amongst the young unwardly mobile, but increasingly in all walks of life, is a relatively new phenomenon in India. Since there is a known connection between stress and diabetes mellitus, those who are under stress and/or lead an irregular lifestyle, need to take adequate precautions and make necessary lifestyle adjustments.

Pancreatic insufficiency caused by stress, can lead to diabetes. Grief, worry and anxiety resulting from examinations, death of a close relative, loss of a joy, business failure and strained marital relationship, all a deep influence on the metabolism and may cause sugar to appear in the urine.

Organic Disorders

Diabetes may be associated with some grave organic disorders like cancer, tuberculosis and cerebral diseases. Diabetes may also be caused by a variety of other factors. These include certain metabolic and genetic disorders, inadequate secretion of insulin by the pancreas, malfunctioning of other endocrine glands like thyroid, pituitary and adrenal, excessive consumption of alcohol and the use of the certain drugs.

Race

Although the reasons are unclear, people of certain races are more likely to develop diabetes than others.

Dr John Anne is a herbal specialist with years of experience and extensive research on Herbs and Alternative health. For more helpful information visit Diabetes Causes at Diabetes Treatment Website. Also read about Diabetes Testing.

Title – Alternative Medicine for the Treatment of Diabetes

Bhupesh Chandra Semwal 1* Sonia Singh1, Dr. Kalyani Divakar2

Introduction-Diabetes mellitus often referred to simply as diabetes. Diabetes is a syndrome characterized by disordered metabolism and abnormally high blood sugar, hyperglycemia resulting from insufficient levels of the hormone insulin. The world health organization recognizes three main forms of diabetes mellitus type1 type2 and gestational diabetes. Gestational diabetes occurring during pregnancy. Which have different causes and population distributions. While, ultimately, all forms are due to the beta cells of the pancreas being unable to produce sufficient insulin to prevent hyperglycemia, the causes are different. All types have been treatable since insulin became medically available in 1921. Type 1 diabetes, in which insulin is not secreted by the pancreas, is directly treatable only with injected insulin, although dietary and other lifestyle adjustments are part of management. Type 2 may be managed with a combination of dietary treatment, tablets and injections and, frequently, insulin supplementation. While insulin was originally produced from natural sources such as porcine pancreas, most insulin used today is produced through genetic engineering, either as a direct copy of human insulin, or human insulin with modified molecules that provide different onset and duration of action. Insulin can also be delivered continuously by a specialized pump which subcutaneously provides insulin through a changeable catheter1.

Classification of diabetes-
Type one diabetes mellitus
Type two diabetes mellitus
Gestational diabetes mellitus2
Signs and symptoms-

Frequent urination, Excessive thirst, Extreme hunger, unusual weight loss, Increased fatigue, Irritability, Blurry vision 3

Top Risk Factors for Type 2 Diabetes

Obesity

An excessively high body weight increases diabetes risk. The Body Mass Index ( BMI) is a simple, widely accepted means of assessing body weight in relation to health for most people aged 20 to 65 (Exceptions include people who are very muscular, athletes, pregnant or nursing.) A BMI greater than 27 indicates a risk for developing type 2 diabetes and other health problems which include cardiovascular disease, and premature death.

Apple-shaped figure

Individuals who carry most of their weight in the trunk of their bodies (i.e., above the hips) tend to have a higher risk of diabetes than those of similar weight with a pear-shaped body (excess fat carried mainly in the hips and thighs). A waist measurement of more than 100 cm (39.5 inches) in men and 95 cm (37.5 inches) in women suggests an increased risk.

Sedentary lifestyle

Being overweight – another risk factor for Type 2 – can be prevented by regular physical activity. A second, independent benefit of regular physical activity is improved blood sugar control in persons who already have type 2 diabetes.

Unhealthy Eating Habits

Ninety% of people who have been diagnosed with type 2 diabetes are overweight. Unhealthy eating contributes largely to obesity. Too much fat, not enough fiber, and too many simple carbohydrates all contribute to a diagnosis of diabetes. Eating right is can turn the diagnosis around and reverse or prevent Type 2.

Increased Age

            It’s a sad but true fact. Age increases the risk of type 2 diabetes.  The older we get, the greater our risk of type 2 diabetes. Even if an elderly person is thin, they still may be predisposed to getting diabetes. Scientists theorize that the pancreas ages right along with us, and doesn’t pump insulin as efficiently as it did when we were younger. Also, as our cells age, they become more resistant to insulin as well.

 High Blood Pressure and High Cholesterol

            High BP and high cholesterol are the hallmark risk factors for many diseases and conditions, including type 2 diabetes. More than 40 percent of people with diabetes have abnormal levels of cholesterol and similar fatty substances that circulate in the blood. These abnormalities appear to be associated with an increased risk of cardiovascular disease among persons with diabetes.

Family History and Genetics

            It appears that people who have family members who have been diagnosed with type 2 diabetes are at a greater risk for developing it themselves. African Americans, Hispanic-Americans and Native Americans all have a higher than normal rate of type 2 diabetes.

History of Diabetes in Pregnancy

            Nearly 40 percent of the women who have diabetes during their pregnancy go on to develop type 2 diabetes later, usually within five to ten years of giving birth. Giving birth to a baby that weighs more than nine pounds (4 kg) is another symptom of gestational diabetes.

Impaired Glucose Tolerance

            Impaired glucose tolerance or impaired fasting glucose can precede the development of type 2 diabetes. These conditions are determined through blood tests. While persons affected with these problems do not meet the diagnostic criteria for diabetes, their blood sugar control and reaction to sugar loads are considered to be abnormal. This places them at higher risk, not just for the development of type 2 diabetes (an estimated one in ten progress to type 2 diabetes within five years), but also for cardiovascular disease. For this group, preventive strategies including lifestyle changes and regular screening for diabetes mellitus must be a priority4.

Alternative medicine for treatment of diabetes

 Ginseng –Although there are several different types of ginseng, most of the promising studies on ginseng and diabetes have used North American ginseng (Panax quinquefolius). Those studies have shown that North American ginseng may improve blood sugar control and glycosylated hemoglobin (a form of hemoglobin in the blood used to monitor blood glucose levels over time) levels.

 Chromium-    Chromium is an essential trace mineral that plays an important role in carbohydrate and fat metabolism and helps body cells properly respond to insulin.

 Magnesium-  Magnesium is a mineral found naturally in foods such as green leafy vegetables, nuts, seeds, and whole grains and in nutritional supplements.Magnesium is needed for more than 300 biochemical reactions. It helps regulate blood sugar levels and is needed for normal muscle and nerve function, heart rhythm, immune function, blood pressure, and for bone health. Some studies suggest that low magnesium levels may worsen blood glucose control in type 2 diabetes. There is also some evidence that magnesium supplementation may help with insulin resistance.

Cinnamon-Cinnamon is a glycosides it improves blood glucose control in people with type 2 diabetes.

 Zinc-   The mineral zinc plays an important role in the production and storage of insulin. There is some research showing that people with type 2 diabetes have suboptimal zinc status due to decreased absorption and increased excretion of zinc. Food sources of zinc include fresh oysters, ginger root, lamb, pecans, split peas, egg yolk, rye, beef liver, lima beans, almonds, walnuts, sardines, chicken, and buckwheat.

 Aloe Vera Gel-Although aloe vera gel is better known as a home remedy for minor burns and other skin conditions, recent animal studies suggest that aloe vera gel may help people with diabetes. A Japanese study evaluated the effect of aloe vera gel on blood sugar. Researchers isolated a number of active phytosterol compounds from the gel that were found to reduce blood glucose and glycosylated hemoglobin levels.

Gymnema Several preliminary studies suggest that the herb gymnema can lower blood sugar levels in people with type 2 diabetes. Because gymnema may lower blood sugar levels, people taking medications for diabetes or using insulin shouldn’t take gymnema unless they are closely monitored by their health care provider

VanadiumVanadium is a trace mineral found naturally in soil and many foods. It is also produced during the burning of petroleum. Vanadium has been found to improve insulin sensitivity and reduce blood sugar in people with type 2 diabetes. It appears to mimic many of the actions of insulin in the body. The use of vanadium for diabetes, particularly without the supervision of a qualified health care practitioner, is not recommended, because the dose needed to affect blood glucose levels can be potentially toxic. The typical amount of vanadium found in the average diet (less than 30 micrograms per day) appears to have little toxicity5.

Neem– The leaves of Neem posses’ anti-diabetic properties. The juices of these leaves are helpful in controlling the blood sugar level in diabetics. Neem is in fact an herbal medicine used for the treatment of various other diseases also such as skin problems, warm infections, ulcer etc.

Sweet potato leaves– The leaves of sweet potato are high value in preventing diabetes, by lowering blood sugar level. It is highly nutritious vegetable. Preparation of sweet potato leaves is used in the tea of diabetic patients.

Madhuca- The Indian name for Madhuca is Madhua it is also posses’ excellent anti-diabetic properties and it is highly beneficial in treating raised blood sugar levels.

Mango leaves– The leaves of Mango helps in lowering the blood sugar levels in diabetics. The fresh leaves of mango are socked in water for an overnight. Then they are squeezed well in the water before filtering them in the morning6.

 Discussion and Conclusion– Managements of diabetes with the agents devoid of any side effects is still challenge for the medical system. This has lead to increase in the demand for natural products with antihyperglycemic activity having fewer side effects. Metabolic imbalance causing diabetes mellitus is a characteristic of materialistic world. Differences in social structure, psychic stress, obesity, hormonal imbalance and heredity are optimizing the growth of pandemic. Increasing population with diabetes has a huge requirement of effective remediation. The vast variety of medicinal plants, which are used traditionally for their anti-diabetic property. However, careful assessment including sustainability of such herbs, ecological and seasonal variation in activity of phyto-constituents, metal contents of crude herbal anti-diabetic drugs, thorough toxicity study and cost effectiveness is required for their popularity. These efforts may provide treatment for all and justify the role of novel traditional medicinal plants having anti-diabetic potentials.

 

References

http://www.diabetesmellitus-information.com/diabetes_herbs.htm

http://www.umm.edu/ency/article/002072.htm

http://www.diabetes.org/diabetes-symptoms.jsp

http://www.phac-aspc.gc.ca/ccdpc-cpcmc/diabetes-diabete/english/risk/index.html

http://altmedicine.about.com/cs/conditionsatod/a/Diabetes.htm

http://www.diabetesmellitus-information.com/diabetes_treatment.htm

 

Bhupesh Chandra Semwal

Lecture Pharmacology,GLAIPR Mathura


Sonia Singh

Lecture Pharmacognosy,GLAIPR Mathura


Dr.Kalyani Divakar

HOD OF pharmacology Acharya & B.M Reddy College of Pharmacy Bangalore